Ion channel path of cellular transduction

Transient receptor potential ion channel function in sensory transduction and cellular signaling cascades underlying visceral hypersensitivity.

Visceral hypersensitivity is an important mechanism underlying increased abdominal pain perception in functional gastrointestinal disorders including functional dyspepsia, irritable bowel syndrome, and inflammatory bowel disease in remission. Although the exact pathophysiological mechanisms are poorly understood, recent studies described upregulation and altered functions of nociceptors and the...

Sequence Alignment of Viral Channel Proteins with Cellular Ion Channels

Sequence alignment is an important tool for identifying regions of similarities among proteins and for, thus, establishing functional and structural relationships between different proteins. Here, alignments of transmembrane domains (TMDs) of viral channel forming proteins with host ion channels and toxins are evaluated. The following representatives of polytopic viral channel proteins are chos...

PERSPECTIVE Neurogastroenterology and Motility Transient receptor potential ion channel function in sensory transduction and cellular signaling cascades underlying visceral hypersensitivity

Balemans D, Boeckxstaens GE, Talavera K, Wouters MM. Transient receptor potential ion channel function in sensory transduction and cellular signaling cascades underlying visceral hypersensitivity. Am J Physiol Gastrointest Liver Physiol 312: G635–G648, 2017. First published April 6, 2017; doi:10.1152/ajpgi.00401.2016.— Visceral hypersensitivity is an important mechanism underlying increased abd...

Ion channel activity drives ion channel expression.

Mechanisms of Cellular Signal Transduction

Editorial Signal transduction is essential for almost all aspects of eukaryotic cell function and for the development of metazoans. In the classic case of signaling mediated by a growth factor, binding of the hormone to its receptor initiates a process that starts with the autoor cross-phosphorylation of the receptor. The activating signal is then propagated through intracellular signaling path...